[Objectives] In order to reduce the workload to numerically calculate acceleration responses of FPSO spatial points at the ship design stage and improve the efficiency of spatial point acceleration prediction, a spatial interpolation technique based on the inverse distance weighted interpolation method is introduced to interpolate acceleration responses of FPSO spatial points for the prediction. [Methods] The spatial interpolation technique interpolates acceleration responses of target points based on acceleration values of FPSO spatial sample points, i.e., acceleration values of spatial sample points are obtained through numerical simulation at first, and a spatial interpolation model based on the inverse distance weighted interpolation method is established to predict acceleration responses of target points by using spatial interpolation, then the accuracy of spatial interpolation results is verified by cross validation, and finally the parameter effects on interpolation forecast accuracy are analyzed. [Results] The results show that the application of spatial interpolation technique can achieve relatively accurate forecasting results, and the accuracy of interpolation prediction for FPSO spatial point acceleration response is high enough, with a maximum error of 12.3%. [Conclusions] The research findings provide a reference for the spatial point acceleration response prediction for an FPSO in the design stage, and the spatial interpolation technique can be spread and applied in the design of the other floating structures.