In order to study the primary and secondary relationship of influencing factors of horizontal displacement of large diameter deep buried pile foundation under wave action, considering the influence of environment, structure and foundation, the orthogonal numerical simulation test of 6 factors and 5 levels was carried out by ABAQUS software. The calculation results show that for the maximum displacement difference of the pile top, the primary and secondary relationship of sensitivity is : wave height > water depth > pile diameter > Poisson 's ratio > buried depth > friction angle ; the maximum displacement difference of the pile foundation mud surface point, the primary and secondary relationship of sensitivity is : wave height > buried depth > Poisson 's ratio > water depth > pile diameter > friction angle. In addition, according to the index trend diagram, it can be clearly concluded that the maximum displacement of the pile top is positively correlated with the water depth ; the maximum displacement of the mud surface point of the pile foundation is positively correlated with the wave height ; the maximum displacement of the pile foundation mud surface point is negatively correlated with the buried depth. The results of variance analysis show that water depth and wave height have a significant effect on the maximum displacement of pile top. At the same time, the wave height has a significant effect on the displacement of the pile foundation mud surface.