The stable and reliable operation of cold-water pipes is the key to thermoelectric power generation, but the current research rarely considers the dynamic response under the combined excitation of internal current, ocean current and wave. Based on the theory of Euler-Bernoulli beam and Morrison equation, this paper comprehensively considers the effect of environmental loads, establishes the motion equation of the cold sea water pipe, and further uses the Orcaflex software to establish a simulation model. correctness. The effects of wall thickness and mass of counterweight on the natural frequency are studied. The results show that the amplitude of the cold-water pipe decreases with the increase of the water depth; the fifth-order Stokes wave has a greater influence on the maximum Mises stress, bending stress, top flexible joint and lateral vibration of the cold-water pipe than the JONSWAP wave; the natural frequency increases with the cold-water. The thickness of the pipe wall and the mass of the counterweight increase. The research results of this paper have a certain guiding effect on the design of cold-water pipes.